干燥综合征唇腺的组织化学研究。

Histochemical study of labial salivary glands in Sjögren's syndrome.

作者信息

Fava-De-Moraes F, Friedman H, Egami M I, Bevilacqua E M, Cossermelli W

出版信息

J Oral Pathol. 1978 Jun;7(3):135-42. doi: 10.1111/j.1600-0714.1978.tb01589.x.

DOI:10.1111/j.1600-0714.1978.tb01589.x

Abstract

Human labial salivary gland biopsies of patients presenting connective tissue diseases associated with Sjögren's syndrome were submitted to a polysaccharide histochemistry study. The normal acinar secretion is an association of neutral polysaccharides with a sulphosialomucin. In Sjögren's syndrome, there is a great reduction in the secretory activity of the acinar cells, but no qualitative change was observed. The pathogenesis of this decreased production and its importance regarding the clinical manifestations of Sjögren's syndrome are discussed.

摘要

对患有与干燥综合征相关的结缔组织疾病的患者的人唇唾液腺活检组织进行了多糖组织化学研究。正常腺泡分泌物是中性多糖与硫代唾液酸粘蛋白的结合物。在干燥综合征中，腺泡细胞的分泌活性大幅降低，但未观察到质的变化。本文讨论了这种分泌减少的发病机制及其与干燥综合征临床表现的关系。