Lu W B, Wen R X, Guan C F
China Academy of Traditional Chinese Medicine, Beijing.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 May;17(5):271-3.
For the first time, serum anti-HIV antibody negative conversion was being reported.
Eight confirmed HIV/AIDS patients (AC1, ARC 6, AIDS 1) were treated with TCM recipes (802, 806, 809, 810, Shengmaiyin, ZY-1), recheck the serum antibody and immunological function and intranuclear HIV-DNA was investigated with PCR amplifying assay and were long-term followed-up.
After medication for 87-463 days, seronegative conversion occurred, PCR assay revealed that 5 cases were PCR(+), 2 of them(-), 1 turned seropositive again in the early stage. Observed continuously for 11-49 months, the "serum negative and intranuclear positive" state maintained. These patients belonged to immunosilent HIV-infection. The immunological function of all seronegative converted patients were good.
AIDS is a reversible disease. Using medicinal herbs to enhance the immune function will facilitate the appearance of seronegative conversion, which has not been reported before. If it could be further confirmed, its mechanism elucidated, this may greatly strengthen the confidence of the patients.
首次报道血清抗HIV抗体阴转情况。
对8例确诊的HIV/AIDS患者（AC1例、ARC 6例、AIDS 1例）采用中药方剂（802、806、809、810、生脉饮、ZY - 1）进行治疗，复查血清抗体及免疫功能，并采用PCR扩增法检测核内HIV - DNA，进行长期随访。
用药87 - 463天后出现血清学阴转，PCR检测显示5例为PCR(+)，2例为(-)，1例在早期再次转为血清阳性。持续观察11 - 49个月，维持“血清阴性且核内阳性”状态。这些患者属于免疫沉默型HIV感染。所有血清学阴转患者的免疫功能良好。
艾滋病是一种可逆性疾病。使用草药增强免疫功能将促使血清学阴转的出现，此前未见报道。若能进一步证实并阐明其机制，可能会极大增强患者的信心。
