Matsushima S, Maruyama T, Torii M
Division of Toxicological Pathology, Developmental Research Laboratories of Shionogi Co., Ltd., Toyonaka, Osaka, Japan.
Toxicol Pathol. 1998 Nov-Dec;26(6):806-9. doi: 10.1177/019262339802600614.
A peripheral neuroblastoma was found in the abdominal cavity of a young male beagle dog. The large tumor mass involved the left kidney and both adrenal glands. Histologically, a major portion of the neoplasm consisted of lobulated sheets of small round cells with hyperchromatic nuclei mixed with polygonal cells and neuropil. Small clusters of polygonal cells with abundant eosinophilic cytoplasm and a trabecular growth pattern were observed adjacent to some of the tumor lobules. Small, round neoplastic cells metastasized to lumbar lymph nodes and also to the adrenal glands. The neoplastic cells were positive for neuron-specific enolase, synaptophysin, and neurofilament protein. Electron micrographs revealed intracytoplasmic dense core granules, microtubules, intermediate filaments, and desmosomes in the cytoplasm of the neoplastic cells.
在一只年轻雄性比格犬的腹腔中发现了一例外周神经母细胞瘤。巨大的肿瘤块累及左肾和双侧肾上腺。组织学上，肿瘤的大部分由小叶状的小圆形细胞片组成，细胞核深染，混有多边形细胞和神经毡。在一些肿瘤小叶附近观察到小簇具有丰富嗜酸性细胞质和小梁状生长模式的多边形细胞。小的圆形肿瘤细胞转移至腰淋巴结，也转移至肾上腺。肿瘤细胞对神经元特异性烯醇化酶、突触素和神经丝蛋白呈阳性反应。电子显微镜照片显示肿瘤细胞质内有致密核心颗粒、微管、中间丝和桥粒。
