99m锝甲氧基异丁基异腈俯卧位乳腺闪烁造影术在乳腺佩吉特病中的应用：一例报告

99m Tc MIBI prone scintimammography in breast Paget's disease: a case report.

作者信息

Mezi S, Scopinaro F, Marzullo A, Sallusti E, David V, Ierardi M, Tiberio N S, Modesti M

机构信息

Servizio Speciale di Oncologia, Dipartimento di Medicina Sperimentale e Patologia, I-00161 Rome, Italy.

出版信息

Oncol Rep. 1999 Jan-Feb;6(1):45-8. doi: 10.3892/or.6.1.45.

DOI:10.3892/or.6.1.45

PMID:9864399

Abstract

A 99m Tc MIBI prone scintimammography (PSM) was performed in a case of underlying Paget's disease of the breast. 99m Tc MIBI PSM showed a diffuse scintigraphic image like a spread of uptake from the deeply located zones of the breast toward epidermis. In vivo, 99m Tc MIBI PSM represents the spread of neoplastic Paget's cells probably attracted by chemotactic factors released by keratinocytes. This spread in Paget's disease is correlated to neu oncogene overexpression which increases the metastatic activity as a consequence of motility enhancement and growth stimulation effect. These scintigraphic images suggest that 99m Tc MIBI PSM could be relevant in management of Paget's disease of the breast.

摘要

对一例潜在的乳腺佩吉特病患者进行了99m锝甲氧基异丁基异腈俯卧位乳腺闪烁显像（PSM）。99m锝甲氧基异丁基异腈PSM显示出一种弥漫性的闪烁图像，就像摄取物从乳腺深部区域向表皮扩散一样。在活体中，99m锝甲氧基异丁基异腈PSM代表了可能被角质形成细胞释放的趋化因子吸引的肿瘤性佩吉特细胞的扩散。佩吉特病中的这种扩散与neu癌基因的过度表达相关，该基因由于运动增强和生长刺激作用而增加转移活性。这些闪烁图像表明，99m锝甲氧基异丁基异腈PSM在乳腺佩吉特病的管理中可能具有重要意义。