成纤维细胞生长因子-9（神经胶质激活因子）无论内源性生长因子是否表达，均可刺激人胶质瘤中神经胶质细胞的增殖及胶质纤维酸性蛋白的产生。
Fibroblast growth factor-9 (glia-activating factor) stimulates proliferation and production of glial fibrillary acidic protein in human gliomas either in the presence or in the absence of the endogenous growth factor expression.
作者信息
Miyagi N, Kato S, Terasaki M, Aoki T, Sugita Y, Yamaguchi M, Shigemori M, Morimatsu M
机构信息
Department of Pathology, Kurume University, School of Medicine, Kurume, Japan.
出版信息
Oncol Rep. 1999 Jan-Feb;6(1):87-92.
We tested fibroblast growth factor-9 (FGF-9) expression in human glioma cells (U251MG, T98G, U87MG, KALS-1, NMC-G1) and only NMC-G1 expressed endogenous FGF-9. All cells expressed bFGF and high affinity receptors for FGFs (FGFR1 and FGFR3). Exogenously supplied bFGF and FGF-9 both showed mitogenic activities in all cells. Neutralizing antibody against bFGF inhibited the proliferation in U251MG and NMC-G1, however that against FGF-9 inhibited the proliferation only in NMC-G1. GFAP expression was stimulated by both FGFs in these cells. FGF-9 potentially regulates proliferation and GFAP expression in human gliomas either in the presence or in the absence of the endogenous growth factor expression.
我们检测了人胶质瘤细胞（U251MG、T98G、U87MG、KALS-1、NMC-G1）中成纤维细胞生长因子9（FGF-9）的表达，只有NMC-G1表达内源性FGF-9。所有细胞均表达碱性成纤维细胞生长因子（bFGF）和FGFs的高亲和力受体（FGFR1和FGFR3）。外源性提供的bFGF和FGF-9在所有细胞中均显示出促有丝分裂活性。抗bFGF的中和抗体抑制了U251MG和NMC-G1中的增殖，然而抗FGF-9的中和抗体仅在NMC-G1中抑制了增殖。在这些细胞中，两种FGF均刺激了胶质纤维酸性蛋白（GFAP）的表达。无论内源性生长因子表达与否，FGF-9都可能调节人胶质瘤中的增殖和GFAP表达。
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