Horiguchi J, Iino Y, Takei H, Maemura M, Yokoe T, Niibe H, Yamakawa M, Nakajima T, Oyama T, Morishita Y
Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma 371-8511, Japan.
Oncol Rep. 1999 Jan-Feb;6(1):135-8.
A total of 161 patients with clinical stage I and II breast cancer received breast-conserving therapy between August 1991 and December 1997, and local recurrence occurred in five patients. The actuarial local control 5 years after breast-conserving surgery was 96.6%. We studied microscopic surgical margins of resected specimens in patients with breast-conserving surgery to determine whether the surgical margin was a risk factor for local recurrence in the conserved breast. Microscopic margins were negative in 125 (78%) of 161 patients and positive in 36 (22%). There were no differences between patients with positive surgical margins and those with negative surgical margins in age at operation, tumor size, clinical stage, lymph node status, estrogen receptor status, or distance from tumor to nipple. Local control was significantly better in the surgical margin-negative patients than in the surgical margin-positive patients. We conclude that microscopic surgical margin is a risk factor for local recurrence in the conserved breast.
1991年8月至1997年12月期间，共有161例临床I期和II期乳腺癌患者接受了保乳治疗，其中5例出现局部复发。保乳手术后5年的精算局部控制率为96.6%。我们研究了保乳手术患者切除标本的显微镜下手术切缘，以确定手术切缘是否是保乳局部复发的危险因素。161例患者中，125例（78%）显微镜下切缘阴性，36例（22%）阳性。手术切缘阳性患者与阴性患者在手术年龄、肿瘤大小、临床分期、淋巴结状态、雌激素受体状态或肿瘤距乳头的距离方面无差异。手术切缘阴性患者的局部控制明显优于手术切缘阳性患者。我们得出结论，显微镜下手术切缘是保乳局部复发的危险因素。
