Mejía C, Navarro S, Colamonici O R, Pellín A, Castel V, Llombart-Bosch A
Department of Pathology, Medical School, University of Valencia, Valencia 46010, Spain.
Oncol Rep. 1999 Jan-Feb;6(1):149-53.
Expression of type I interferon receptor (IFN-R) has been found in several normal tissues and in malignant neoplasms, mainly those with epithelial differentiation. In order to analyze the immunohistochemical expression of type I IFN-R we studied 79 cases of neuroblastoma. Results of expression of type I IFN-R were statistically correlated with histopathology, stage, bcl-2 and PCNA expression, N-myc amplification and apoptosis. We found expression of type I IFN-R in 54/79 cases showing statistical correlation with bcl-2 expression (P=0.017) and favourable histopathology (P=0.015). The overexpression found in ganglion cells suggests that IFN-R could be involved in the pathway of neuroblastoma differentiation. Moreover, the expression of type I IFN-R in stage 4 cases (12/20), even with N-myc amplification (6/8), opens new possibilities for therapeutic management in advanced cases that do not respond to any chemotherapeutic protocol.
I型干扰素受体（IFN-R）已在多种正常组织及恶性肿瘤中被发现，主要是那些具有上皮分化的肿瘤。为了分析I型IFN-R的免疫组化表达，我们研究了79例神经母细胞瘤。I型IFN-R的表达结果与组织病理学、分期、bcl-2和PCNA表达、N-myc扩增及凋亡进行了统计学关联分析。我们发现79例中有54例表达I型IFN-R，其与bcl-2表达（P=0.017）及良好的组织病理学（P=0.015）存在统计学相关性。在神经节细胞中发现的过表达提示IFN-R可能参与神经母细胞瘤的分化途径。此外，I型IFN-R在4期病例（12/20）中的表达，即使伴有N-myc扩增（6/8），也为那些对任何化疗方案均无反应的晚期病例的治疗管理开辟了新的可能性。
