Dement'eva E V, Kruglov I V, Pimenov V K, Semiletov Iu A
Vopr Virusol. 1998 Sep-Oct;43(5):217-20.
Six synthetic peptides from immunodominant region 65-80 aa derived from the sequences of delta-antigen corresponding to 3 HDV genotypes were obtained. Their antigenic activities were assessed by indirect enzyme immunoassay with sera of patients with hepatitis D and of asymptomatic carriers of anti-delta antibodies. Differences in antigenic characteristics of full-size 65-80 and truncated 71-80 aa peptides corresponding to three HDV genotypes were revealed. The diagnostic significance of synthetic 65-80 aa fragments is shown.
