Hoekx L, Jeuris W, Van Marck E, Wyndaele J J
Department of Urology, University Hospital Antwerp, Belgium.
Acta Urol Belg. 1998 Oct;66(3):1-2.
Prostatic subclinical inflammation is associated with elevated serum prostate specific antigen (PSA) level when there is contact with and disruption of the glandular epithelium of the prostate. This aggressiveness of the inflammation was graded on a 4-point scale proposed by Irani (1). Patients with an elevated serum PSA level and no malignancy in their transrectal prostate biopsy, have a lower risk of biopsy missed prostate carcinoma when there is an inflammation with a high aggressiveness score. The density itself of the inflammatory cells in the prostatic tissue was not associated with the serum PSA level. We believe that both issues should be considered when interpreting a prostate biopsy.
当前列腺腺上皮受到接触和破坏时，前列腺亚临床炎症与血清前列腺特异性抗原（PSA）水平升高有关。这种炎症的侵袭性根据Irani（1）提出的4级量表进行分级。血清PSA水平升高且经直肠前列腺活检未发现恶性肿瘤的患者，当炎症侵袭性评分较高时，活检漏诊前列腺癌的风险较低。前列腺组织中炎症细胞的密度本身与血清PSA水平无关。我们认为在解读前列腺活检结果时应同时考虑这两个问题。
