Palomera L, Azaceta G, Varo M J, Soria J, Gutierrez M
Haematologica. 1998 Nov;83(11):1045-6.
We report a case of fulminant myelofibrosis after administration of fludarabine in a patient diagnosed as having refractory low-grade lymphoma, progressing fatally. Myelofibrosis in the setting of an indolent lymphoma is very rare; this fact, and the short period between drug administration and fibrosis suggest an etiopathogenic link, although this potential and severe adverse effect of fludarabine has not been previously reported in the literature.
我们报告了一例在被诊断为难治性低度淋巴瘤的患者中，使用氟达拉滨后发生暴发性骨髓纤维化并最终致命的病例。惰性淋巴瘤背景下的骨髓纤维化非常罕见；这一事实，以及给药与纤维化之间的短时间间隔提示了一种病因学联系，尽管氟达拉滨的这种潜在严重不良反应此前尚未见诸文献报道。
