Póvoa R, Bombing M T, Luna Filho B, Simões M, Costa A, Murad N, Ferreira C, Ferreira Filho C
Escola Paulista de Medicina-UNIFESP São Paulo, Brasil.
Rev Port Cardiol. 1998 Oct;17(10):803-7.
The CARE study showed that the myocardial infarction recurrence rate in patients with moderate cholesterol blood level decreases early during pravastatin treatment. Our goal is to evaluate the possible role of pravastatin in preventing the myocardial lesions induced by cold stress. Twenty Wistar-EPM rats were divided into four groups: Control (CON); PR (Pravastatin) treated with 10 mg/kg/d for 15 days; S (Stress group) in which the rats were submitted to cold stress (-8 degrees C for four hours); and PR + S group treated with pravastatin like PR group and also submitted to the cold stress. The animals were sacrificed and heart fragments were removed for optic and electronic microscopic analysis. The variable considered was mitochondria abnormality (edema, lyses and vacuolization) that was interpreted as crystolyses indices (CI) (n degree of abnormal mitochondria/n degree total of mitochondria). The following crystolyses indices, were found for each group respectively: CON, 2.0%; S, 95.5%; PR, 19.9% and PR + S group, 27.7%*(*p < 0.01). In conclusion, pravastatin prevented myocardial lesions induced by cold stress significantly.
CARE研究表明，血液胆固醇水平中等的患者在普伐他汀治疗早期，心肌梗死复发率会降低。我们的目标是评估普伐他汀在预防冷应激诱导的心肌损伤中可能发挥的作用。将20只Wistar-EPM大鼠分为四组：对照组（CON）；普伐他汀（PR）组，以10mg/kg/d的剂量治疗15天；应激组（S），大鼠接受冷应激（-8℃，持续4小时）；PR + S组，像PR组一样接受普伐他汀治疗，并同时接受冷应激。处死动物后，取出心脏组织用于光学和电子显微镜分析。所考虑的变量是线粒体异常（水肿、溶解和空泡化），将其解释为晶体溶解指数（CI）（线粒体异常数量/线粒体总数）。每组分别发现以下晶体溶解指数：CON组为2.0%；S组为95.5%；PR组为19.9%；PR + S组为27.7%*（*p < 0.01）。总之，普伐他汀能显著预防冷应激诱导的心肌损伤。
