Murakami Y, Yamashita Y, Matsuishi T, Iwanaga R, Kato H
Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume City, Fukuoka, Japan.
Brain Dev. 1998 Dec;20(8):574-8. doi: 10.1016/s0387-7604(98)00053-9.
We continuously monitored changes in cerebral oxygenation and hemodynamics in the frontal lobes of six patients with Rett syndrome during the awake state, which is associated with hyperventilation (HV) and breath-holding (BH), and during sleep by near-infrared spectroscopy. We also monitored three adult volunteers during simulated episodes of HV and BH. In patients with Rett syndrome, the oxygenated hemoglobin (HbO2) and total hemoglobin (HbT) decreased significantly during HV and BH in the awake state compared with the sleep state. The HbO2 and HbT decreased gradually in adult volunteers in response to prolonged episodes of HV and BH. Further studies are required to investigate the relationship, if any, between the discovered continuous decreases in HbO2 and HbT during the awake state and the brain damage seen in patients with Rett syndrome.
我们通过近红外光谱法持续监测了6名雷特综合征患者在清醒状态（与换气过度（HV）和屏气（BH）相关）以及睡眠期间额叶的脑氧合和血流动力学变化。我们还在模拟的HV和BH发作期间监测了3名成年志愿者。在雷特综合征患者中，与睡眠状态相比，清醒状态下HV和BH期间的氧合血红蛋白（HbO2）和总血红蛋白（HbT）显著降低。成年志愿者在长时间的HV和BH发作后，HbO2和HbT逐渐下降。需要进一步研究来调查清醒状态下发现的HbO2和HbT持续下降与雷特综合征患者脑损伤之间是否存在关系。
