Li J, Simpson L, Takahashi M, Miliaresis C, Myers M P, Tonks N, Parsons R
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Cancer Res. 1998 Dec 15;58(24):5667-72.
PTEN/MMAC1 is a tumor suppressor gene that is mutated in a variety of cancers. PTEN encodes a phosphatase that recognizes phosphoprotein substrates and the phospholipid, phosphatidylinositol-3,4,5-triphosphate. PTEN inhibited cell growth and/or colony formation in all of the epithelial lines tested with one exception. The decrease in cellular proliferation was associated with an induction of apoptosis and an inhibition of signaling through the phosphatidylinositol 3'-kinase pathway. Akt/protein kinase B, a gene whose antiapoptotic function is regulated by phosphatidylinositol-3,4,5-triphosphate, was able to rescue cells from PTEN-dependent death. PTEN, therefore, appears to suppress tumor growth by regulating phosphatidylinositol 3'-kinase signaling.
PTEN/MMAC1是一种肿瘤抑制基因，在多种癌症中发生突变。PTEN编码一种磷酸酶，该磷酸酶可识别磷蛋白底物和磷脂酰肌醇-3,4,5-三磷酸。除一个例外情况外，PTEN在所有测试的上皮细胞系中均抑制细胞生长和/或集落形成。细胞增殖的减少与细胞凋亡的诱导以及通过磷脂酰肌醇3'-激酶途径的信号传导抑制有关。Akt/蛋白激酶B是一种抗凋亡功能受磷脂酰肌醇-3,4,5-三磷酸调节的基因，它能够使细胞从依赖PTEN的死亡中获救。因此，PTEN似乎通过调节磷脂酰肌醇3'-激酶信号传导来抑制肿瘤生长。
