Man'kovs'ka I M, Serebrovs'ka Z O
A. A. Bogomolets Institute of Physiology, National Academy of Science of the Ukraine, Kiev.
Fiziol Zh (1994). 1998;44(5-6):118-25.
Reactive oxygen species in low doses are necessary compound of sperm capacitation and hyperactivation. Superoxide anion, hydroxyl radical and hydrogen peroxide initiate sperm capacitation. The edding of antioxidant enzymes inhibits the spontaneous and induced sperm hyperactivation. The process of capacitation is accompanied with the superoxide anion production output by spermatozoa. High doses of reactive oxygen species block the sperm motility through the inhibition of ATP synthesis by the mitochondrial enzymes and cell membrane compounds injury.
低剂量的活性氧是精子获能和超激活的必要组成部分。超氧阴离子、羟基自由基和过氧化氢启动精子获能。抗氧化酶的缺失会抑制自发和诱导的精子超激活。获能过程伴随着精子产生超氧阴离子。高剂量的活性氧通过抑制线粒体酶的ATP合成和损伤细胞膜成分来阻断精子运动。
