志贺氏菌与氟喹诺酮类药物
Shigella and the fluorinated quinolones.
作者信息
Ballal M, Chandran A, Mathew M, Shivananda P G
机构信息
Department of Microbiology, Kasturba Medical College, Manipal.
出版信息
Indian J Pathol Microbiol. 1998 Oct;41(4):453-6.
Between July 1996 to June 1997 a total of 531 Stool samples from cases of acute diarrhoea, dysentry, colitis admitted to Kasturba Medical College Hospital, Manipal were investigated. Shigella were isolated from 29 samples (5.46%). Out of them, Shigella flexneri were 16 (55.17%), Shigella boydii 8 (27.58%), Shigella dysentriae 3 (10.34%) and Shigella sonnei 2 (6.89%). Five strains of Shigella flexneri and one strain of Shigella dysentriae were found to show resistance to Nalidixic acid and the newer fluoroquinolones viz., Ciprofloxacin, Norfloxacin and Ofloxacin. The in vitro 'R' factor transfer study showed that the resistance was not transferable.
1996年7月至1997年6月期间，对马尼帕尔卡斯图尔巴医学院医院收治的急性腹泻、痢疾、结肠炎病例的531份粪便样本进行了调查。从29份样本（5.46%）中分离出志贺氏菌。其中，福氏志贺氏菌16株（55.17%），鲍氏志贺氏菌8株（27.58%），痢疾志贺氏菌3株（10.34%），宋内志贺氏菌2株（6.89%）。发现5株福氏志贺氏菌和1株痢疾志贺氏菌对萘啶酸及新型氟喹诺酮类药物（即环丙沙星、诺氟沙星和氧氟沙星）耐药。体外“R”因子转移研究表明，这种耐药性不可转移。
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