Aronna G, De Rosa A, Rosso F, Margarucci S, Caruso F
Istituto di Clinica Odontoiatrica e Stomatologia, Seconda Università degli Studi, Napoli.
Minerva Stomatol. 1998 Oct;47(10):553-7.
A clinical and microscopical (SEM) investigation has been carried out on the biocompatibility of cellulose acetate fiber tetracycline with 25% of tetracycline hydrochloride (Actisite R). A subject with advanced periodontal disease was selected and a pocket of 8 mm of PD was chosen. A segment of fiber was inserted into the pocket for 8 days. After removal, PD and GI clinical parameters were detected and the fiber removed was analyzed at the scanning electronic microscope. The results showed clinical signs of inflammation after removal of fiber. SEM analysis showed macrophagic reaction, a typical sign of inflammatory response to material. The study suggests the need of more biocompatible materials, easier to use as delivery system of antibiotics in the treatment of periodontal disease.
已对含25%盐酸四环素的醋酸纤维素纤维四环素（Actisite R）的生物相容性进行了临床和显微镜（扫描电子显微镜）研究。选择了一名患有晚期牙周病的受试者，并选取了一个牙周袋深度为8毫米的部位。将一段纤维插入牙周袋8天。取出后，检测牙周袋深度和牙龈指数等临床参数，并对取出的纤维在扫描电子显微镜下进行分析。结果显示取出纤维后有炎症的临床迹象。扫描电子显微镜分析显示有巨噬细胞反应，这是对材料炎症反应的典型迹象。该研究表明需要更具生物相容性的材料，以便在牙周病治疗中更易于用作抗生素的递送系统。
