神经病变作为慢性肝病的一种肝外表现。

Neuropathy as an extrahepatic manifestation of chronic liver diseases.

作者信息

Szalay F, Marton A, Keresztes K, Hermányi Z S, Kempler P

机构信息

First Dept. of Medicine, Semmelweis University, Budapest, Hungary.

出版信息

Scand J Gastroenterol Suppl. 1998;228:130-2. doi: 10.1080/003655298750026660.

DOI:10.1080/003655298750026660

PMID:9867123

Abstract

Gastrointestinal motor disturbances and various cardiovascular symptoms are the characteristic features of autonomic neuropathy. Autonomic and sensory neuropathy has been described in chronic alcoholic liver diseases. Cardiovascular autonomic reflex tests as the gold standard for autonomic neuropathy and measuring of thresholds for constant current electric sine wave stimulation by neurometer were used for measuring sensory neuropathy in patients with chronic liver diseases of different etiology. Autonomic and sensory neuropathy was also observed in non-alcoholic liver diseases. We proved that there is a correlation between autonomic neuropathy and prolongation of corrected QT interval in chronic liver diseases. We claim that autonomic neuropathy may have a role to play in the development of hyperdynamic circulation and portal hypertension in chronic liver diseases.

摘要

胃肠道运动障碍和各种心血管症状是自主神经病变的特征性表现。自主神经和感觉神经病变已在慢性酒精性肝病中有所描述。心血管自主反射测试作为自主神经病变的金标准，以及使用神经仪测量恒定电流正弦波刺激的阈值来评估感觉神经病变，被用于检测不同病因慢性肝病患者的感觉神经病变。在非酒精性肝病中也观察到了自主神经和感觉神经病变。我们证实，在慢性肝病中，自主神经病变与校正QT间期延长之间存在关联。我们认为，自主神经病变可能在慢性肝病高动力循环和门静脉高压的发展中起作用。