Dümcke Christine Winkler, Møller Søren
Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark.
Scand J Clin Lab Invest. 2008;68(6):437-47. doi: 10.1080/00365510701813096.
Liver cirrhosis and portal hypertension are frequently associated with signs of circulatory dysfunction and peripheral polyneuropathy, which includes defects of the autonomic nervous system. Autonomic dysfunction, which is seen in both alcoholic and non-alcoholic liver cirrhosis and increases with severity and duration of the liver disease, is associated with a significant increase in mortality. The lack of total resolution after liver transplantation indicates that the autonomic neuropathy is not exclusively functional. This article highlights some aspects of the autonomic dysfunction in chronic liver disease. A description is given of its aetiology and the typical circulatory dysfunction with characteristic hyperdynamic and hyporeactive circulation and heart failure, and the most important tests of the autonomic nervous system.
肝硬化和门静脉高压常伴有循环功能障碍和周围神经病变的体征，其中包括自主神经系统缺陷。自主神经功能障碍在酒精性和非酒精性肝硬化中均有出现，且随着肝脏疾病的严重程度和病程延长而加重，与死亡率显著增加相关。肝移植后自主神经病变无法完全恢复，这表明其并非单纯功能性病变。本文重点介绍了慢性肝病中自主神经功能障碍的一些方面。阐述了其病因、典型的循环功能障碍（具有高动力循环和反应性降低以及心力衰竭等特征）以及自主神经系统的最重要检查。
