Baum J L, Rao G
Am J Ophthalmol. 1976 Sep;82(3):435-8. doi: 10.1016/0002-9394(76)90491-8.
Keratomalacia occurred in two cachectic hospitalized patients, each with severe vitamin A-protein deficiency secondary to a lethal disease. Prompt therapy with parenteral and topical vitamin A, protein supplementation, and a soft contact lens restored corneal integrity and prevented visual loss in one patient. Keratinization of the conjunctiva did not occur in either patient. Patients with severe protein deficiency may develop keratomalacia in the absence of a severely decreased serum level of vitamin A.
两名恶病质住院患者发生了角膜软化症，他们均因致命疾病继发严重的维生素A - 蛋白质缺乏。对其中一名患者迅速采用肠胃外和局部应用维生素A、补充蛋白质以及佩戴软性隐形眼镜进行治疗，恢复了角膜完整性并防止了视力丧失。两名患者均未发生结膜角化。严重蛋白质缺乏的患者在血清维生素A水平未严重降低的情况下也可能发生角膜软化症。
