Peng A, Zhao S, Zhang X, Zhang G
Division of Gastroenterology, Xiangya Hospital, Changsha.
Hunan Yi Ke Da Xue Xue Bao. 1997;22(1):59-62, 65.
Polyamine levels were determined by precolumn derivation RH-HPLC in 68 patients with ascites including 21 malignant ascites, 28 liver cirrhosis and 19 tuberculosis. The total polyamine, especially the contents of cadaverine (CA) and spermidine (SPD) in malignant ascites were significantly higher than that in cirrhosis and tuberculosis. Among them CA levels in malignant ascites and cirrhotic and tubercular ascitic fluid were 2.26 +/- 1.83 nmol.ml-1, 0.75 +/- 0.52 nmol.ml-1 and 0.76 +/- 0.47 nmol.ml-1 respectively, demonstrated the most obvious difference. Using 1.0 nmol.ml-1 as a threshold cut off point to differentiate the malignant ascites from non-malignant ascites, the from non-malignant ascites, the sensitivity, specificity and accuracy reached 76. 2%, 83.0% and 80.9% respectively. The results suggest that polymine level in ascites might be regard as one of the cancer-associated markers.
采用柱前衍生化反相高效液相色谱法（RH-HPLC）测定了68例腹水患者的多胺水平，其中包括21例恶性腹水患者、28例肝硬化患者和19例结核患者。恶性腹水中的总多胺，尤其是尸胺（CA）和亚精胺（SPD）的含量显著高于肝硬化和结核患者。其中，恶性腹水、肝硬化腹水和结核性腹水的CA水平分别为2.26±1.83 nmol·ml-1、0.75±0.52 nmol·ml-1和0.76±0.47 nmol·ml-1，差异最为明显。以1.0 nmol·ml-1作为区分恶性腹水与非恶性腹水的阈值，其敏感性、特异性和准确性分别达到76.2%、83.0%和80.9%。结果表明，腹水中的多胺水平可能被视为癌症相关标志物之一。
