Yuan X, Hu Y, Ye H, Wen Y
Xiangya Hospital, Hunan Medical University, Changsha.
Hunan Yi Ke Da Xue Xue Bao. 1997;22(1):72-4.
Thirty patients with chronic renal insufficiency (CRF) and twenty-six normal subjects were tested with Wechsler Adult Intelligence Scal (WALS). The verbal intelligence quotients (VIQ), performance intelligence quotients (PIQ), and full intelligence quotients (FIQ) of the patients were lower than those of the normal group (P < 0.01). Among them the mild and moderate intelligence damages were accounted 13.33%. Further analysis indicates that uremic posionous materials damage on the cerebral function was dose dependant. But the disease course was independant with the intelligence damage (P > 0.05). The results suggest that the plasma concentrations of uremia poisonous materials (BuN, Scr, etc.) in CRF patients should be lowered as early as possible in order to keep the normal function of the cerebrum.
对30例慢性肾功能不全（CRF）患者和26名正常受试者进行了韦氏成人智力量表（WALS）测试。患者的言语智商（VIQ）、操作智商（PIQ）和总智商（FIQ）均低于正常组（P<0.01）。其中轻度和中度智力损害占13.33%。进一步分析表明，尿毒症毒物对脑功能的损害呈剂量依赖性。但病程与智力损害无关（P>0.05）。结果提示，应尽早降低CRF患者血浆中尿毒症毒物（血尿素氮、血肌酐等）的浓度，以维持大脑的正常功能。
