Vogel H
Department of Pathology, Baylor College of Medicine, Houston, Texas, USA.
Adv Anat Pathol. 1998 May;5(3):164-9. doi: 10.1097/00125480-199805000-00003.
Inclusion body myositis (IBM), a sporadic inflammatory myopathy, is the most frequently occurring progressive myopathy in adults older than 55 years. It more commonly affects men and usually is clinically and pathologically distinguishable from dermatomyositis or polymyositis. Muscle biopsy specimens will display inflammation in virtually all cases of sporadic IBM, along with rimmed vacuoles accompanied by the accumulation of beta-amyloid and other substances similar to those found in the degenerating neurons of Alzheimer's disease. The similarities between IBM and other inflammatory myopathies may contribute to its low level of diagnosis by pathologists. The proper recognition of IBM is important because, unlike other inflammatory myopathies, IBM is unresponsive to anti-inflammatory drugs.
包涵体肌炎（IBM）是一种散发性炎性肌病，是55岁以上成年人中最常见的进行性肌病。它更常累及男性，通常在临床和病理上可与皮肌炎或多发性肌炎相鉴别。在几乎所有散发性IBM病例中，肌肉活检标本都会显示炎症，同时伴有镶边空泡，伴有β-淀粉样蛋白和其他类似于阿尔茨海默病变性神经元中发现的物质的积累。IBM与其他炎性肌病之间的相似性可能导致病理学家对其诊断率较低。正确识别IBM很重要，因为与其他炎性肌病不同，IBM对抗炎药物无反应。
