RET protooncogene analysis in the diagnosis of medullary thyroid carcinoma and multiple endocrine neoplasia type II.

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作者信息

Matias-Guiu X

机构信息

Department of Pathology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain.

出版信息

Adv Anat Pathol. 1998 May;5(3):196-201. doi: 10.1097/00125480-199805000-00058.

DOI:10.1097/00125480-199805000-00058

PMID:9868525

Abstract

摘要

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RET protooncogene analysis in the diagnosis of medullary thyroid carcinoma and multiple endocrine neoplasia type II.

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Analysis of RET protooncogene point mutations distinguishes heritable from nonheritable medullary thyroid carcinomas.RET原癌基因点突变分析可区分遗传性与非遗传性甲状腺髓样癌。

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Molecular and biochemical screening for the diagnosis and management of medullary thyroid carcinoma in multiple endocrine neoplasia type 2A.用于2A型多发性内分泌腺瘤病中甲状腺髓样癌诊断和管理的分子与生化筛查

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Very early detection of RET proto-oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: presence of C-cell malignant disease in asymptomatic carriers.早期检测RET原癌基因突变对于2型多发性内分泌腺瘤病患儿的预防性甲状腺切除术至关重要：无症状携带者中存在C细胞恶性疾病。

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Multiple endocrine neoplasia type 2A with the identical somatic mutation in medullary thyroid carcinoma and pheochromocytoma without germline mutation at the corresponding site in the RET proto-oncogene.2A型多发性内分泌腺瘤病，甲状腺髓样癌和嗜铬细胞瘤存在相同的体细胞突变，而RET原癌基因相应位点无胚系突变。

Intern Med. 1999 Feb;38(2):145-9. doi: 10.2169/internalmedicine.38.145.

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J Cytol. 2010 Apr;27(2):66-8. doi: 10.4103/0970-9371.70745.

Familial non-medullary thyroid carcinoma: an update.家族性非髓样甲状腺癌：最新进展

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