Martínez L A, Braun A M, Oliveros E
Lehrstuhl für Umweltmesstechnik, Engler-Bunte-Institut, Universität Karlsruhe, Karlsruhe, Germany.
J Photochem Photobiol B. 1998 Sep;45(2-3):103-12. doi: 10.1016/s1011-1344(98)00168-7.
The influence of the medium on the quantum yields of singlet oxygen (O2(1 delta g)) production (phi delta) by a series of photosensitizing non-steroidal anti-inflammatory drugs (NSAID) derived from 2-arylpropionic acid (APA) has been investigated. Four-component oil-in-water and water-in-oil microemulsions, based on anionic and cationic surfactants, have been employed as the simplest models to mimic more complex biological environments. phi delta values have been determined by monitoring the singlet oxygen (1O2) luminescence at 1270 nm upon continuous excitation of the drugs under air-equilibrated conditions. Results indicate that phi delta values are highly affected by the medium, being higher in microheterogeneous systems than in (homogeneous) solution. Some of the anti-inflammatory derivatives are very efficient 1O2 sensitizers: e.g., values of apparent phi delta as high as 0.86 (+/- 0.04) and 0.70 (+/- 0.03) have been found for tiaprofenic acid and suprofen, respectively. The location of the drugs in the interfacial region of the microemulsions combined with their high phi delta values suggest that type II reactions may play a significant role in the overall photodynamic process in more complex organized media, such as biological membranes.
研究了介质对一系列源自2-芳基丙酸（APA）的光敏非甾体抗炎药（NSAID）产生单线态氧（O2(1Δg)）的量子产率（φΔ）的影响。基于阴离子和阳离子表面活性剂的四组分水包油和油包水微乳液已被用作最简单的模型，以模拟更复杂的生物环境。通过在空气平衡条件下连续激发药物时监测1270nm处的单线态氧（1O2）发光来确定φΔ值。结果表明，φΔ值受介质的影响很大，在微不均匀体系中比在（均匀）溶液中更高。一些抗炎衍生物是非常有效的1O2敏化剂：例如，分别发现噻洛芬酸和舒洛芬的表观φΔ值高达0.86（±0.04）和0.70（±0.03）。药物在微乳液界面区域的位置及其高φΔ值表明，II型反应可能在更复杂的有组织介质（如生物膜）中的整体光动力过程中起重要作用。
