Müller M, Scheffold C, Lefterova P, Huhn D, Neubauer A, Schmidt-Wolf I G
Abteilung Innere Medizin, Humboldt-Universität Berlin, Germany.
Leuk Lymphoma. 1998 Oct;31(3-4):335-41. doi: 10.3109/10428199809059226.
In autologous bone marrow transplantation, immunologic effector cells such as lymphokine activated killer (LAK) cells may be useful for purging of bone marrow since these cells might have an additional in vivo effect on tumor cells in contrast to other purging protocols. Recently, immunologic effector cells termed cytokine-induced killer (CIK) cells have been shown to be more useful than LAK cells for purging of autologous BM in the context of autologous BMT. Here, we show that the expression of bcr/abl in CIK cells generated from patients with CML correlates with progression of disease in individual patients. In addition, progression of disease from chronic phase to accelerated phase could be predicted in two patients by studying the expression of bcr/abl in CIK cells generated from CML patients. Thus, it might be possible to use CIK cell generation for the prediction of progression of disease in CML patients.
在自体骨髓移植中，免疫效应细胞如淋巴因子激活的杀伤细胞（LAK细胞）可能有助于清除骨髓，因为与其他清除方案相比，这些细胞可能对肿瘤细胞具有额外的体内效应。最近，在自体骨髓移植的背景下，被称为细胞因子诱导的杀伤细胞（CIK细胞）的免疫效应细胞已被证明比LAK细胞更有助于清除自体骨髓。在此，我们表明，慢性粒细胞白血病患者产生的CIK细胞中bcr/abl的表达与个体患者的疾病进展相关。此外，通过研究慢性粒细胞白血病患者产生的CIK细胞中bcr/abl的表达，在两名患者中预测了疾病从慢性期到加速期的进展。因此，利用CIK细胞生成来预测慢性粒细胞白血病患者的疾病进展可能是可行的。
