Sardella A, Carrassi A, Caputo R, Monti M, Gotte P
Department of Oral Pathology and Medicine, School of Dentistry, University of Milan, Italy.
J Clin Periodontol. 1998 Dec;25(12):1047-9. doi: 10.1111/j.1600-051x.1998.tb02412.x.
This report is concerned with gingival manifestations associated with a case of dermochondrocorneal dystrophy (DCCD) or François syndrome occurring in a 42-year-old woman. Our Department treated this patient for 15 years. Oral examination of this case revealed a diffuse enlargement and severe inflammation of the attached gingiva. Systemic findings were similar to those reported in the literature for patients with DCCD. Firm papules 3 mm wide, localized on the face and on the dorsal surface of the hands, were associated with corneal involvement and progressive and severe articular disorder. Because they recurred after surgical ablation, the gingival lesions became an important problem in the management of the patient. After 10 years of unsuccessful treatment limited to scaling, oral hygiene control and mouth rinses with 0.2% chlorexidine solution, the patient was submitted to extraction of the remaining teeth, remodelling osteoplasty and cutaneous graft. An acrylic full denture was inserted. In a follow-up of 7 years, good results for the oral health of the patient were seen.
本报告涉及一名42岁女性所患的皮肤软骨角膜营养不良（DCCD）或弗朗索瓦综合征的牙龈表现。我科对该患者进行了15年的治疗。该病例的口腔检查显示附着龈弥漫性肿大并伴有严重炎症。全身检查结果与文献中报道的DCCD患者相似。3毫米宽的坚实丘疹，局限于面部和手背，伴有角膜受累以及进行性严重关节疾病。由于牙龈病变在手术切除后复发，成为该患者治疗中的一个重要问题。在经过10年仅限于洗牙、口腔卫生控制以及用0.2%洗必泰溶液漱口的治疗但未成功后，患者接受了剩余牙齿的拔除、骨成形术重塑和皮肤移植。随后佩戴了丙烯酸全口义齿。在7年的随访中，患者的口腔健康状况良好。
