Baquero F, García-Rodríguez J A, de Lomas J G, Aguilar L
Microbiology Department, Ramón y Cajal Hospital, Madrid, Spain.
Antimicrob Agents Chemother. 1999 Jan;43(1):178-80. doi: 10.1128/AAC.43.1.178.
A nationwide susceptibility surveillance study of beta-hemolytic streptococcal isolates from pharyngeal swabs obtained in 11 Spanish hospitals between May 1996 and April 1997 against 12 antibiotics was carried out. Of the isolates 86% (786 of 914 isolates) were group A and 8.4% (77 of 914 isolates) were group C. No resistance was found to beta-lactam antibiotics, but significant differences (P < 0.001) with respect to lack of susceptibility to macrolides were found between groups (27% for group A and 12% for group C) and between seasons (13.2% in summer and 31.7% in winter). Most of these isolates displayed the M phenotype (low-level resistance to erythromycin and susceptibility to clindamycin).
1996年5月至1997年4月期间,在西班牙11家医院对从咽拭子中分离出的β-溶血性链球菌进行了一项针对12种抗生素的全国性药敏监测研究。在分离出的菌株中,86%(914株中的786株)为A组,8.4%(914株中的77株)为C组。未发现对β-内酰胺类抗生素耐药,但在不同组(A组为27%,C组为12%)和不同季节(夏季为13.2%,冬季为31.7%)之间,发现对大环内酯类药物敏感性缺乏存在显著差异(P<0.001)。这些分离株大多表现为M表型(对红霉素低水平耐药,对克林霉素敏感)。