Lachkar Y, Migdal C, Dhanjil S
Glaucoma Department, Western Eye Hospital, London, England.
Arch Ophthalmol. 1998 Dec;116(12):1591-4. doi: 10.1001/archopht.116.12.1591.
To study the effect of a selective alpha 2-adrenoreceptor agonist, brimonidine tartrate, on ocular hemodynamics.
Eighteen patients with ocular hypertension were enrolled in a prospective, randomized, double-masked study in which 0.2% brimonidine tartrate, administered twice daily, was compared with its vehicle in a crossover fashion. The effect on the ocular circulation was assessed by color Doppler ultrasound, which measured blood flow velocities (peak systolic and end diastolic velocities) in the central retinal, ophthalmic, nasal, and temporal ciliary arteries. The following tests were performed at 2 weekly intervals on both treatments, 0.2% brimonidine tartrate and the placebo: intraocular pressure, heart rate, blood pressure, and color Doppler ultrasound.
Velocities and resistivity indices measured by color Doppler ultrasound in the ophthalmic artery, central retinal artery, nasal artery, and temporal ciliary arteries showed no statistically significant differences between the placebo and 0.2% brimonidine tartrate when compared with baseline values and between the groups. Intraocular pressure was decreased by 17.7% +/- 9.5% with 0.2% brimonidine tartrate (vs 9% +/- 8% with placebo).
The hemodynamics of the posterior segment of the eye as measured by color Doppler ultrasound do not appear to be altered by 2% brimonidine tartrate.
研究选择性α2-肾上腺素能受体激动剂酒石酸溴莫尼定对眼血流动力学的影响。
18例高眼压患者参与一项前瞻性、随机、双盲研究，采用交叉方式将每日两次给药的0.2%酒石酸溴莫尼定与其赋形剂进行比较。通过彩色多普勒超声评估对眼循环的影响，该超声测量视网膜中央动脉、眼动脉、鼻睫状动脉和颞睫状动脉的血流速度（收缩期峰值和舒张末期速度）。对0.2%酒石酸溴莫尼定和安慰剂这两种治疗，每隔2周进行以下检查：眼压、心率、血压和彩色多普勒超声检查。
与基线值相比，以及在两组之间比较时，彩色多普勒超声测量的眼动脉、视网膜中央动脉、鼻动脉和颞睫状动脉的速度和阻力指数在安慰剂和0.2%酒石酸溴莫尼定之间无统计学显著差异。0.2%酒石酸溴莫尼定使眼压降低了17.7%±9.5%（安慰剂组为9%±8%）。
彩色多普勒超声测量的眼后段血流动力学似乎未因2%酒石酸溴莫尼定而改变。
