Darling J L, Warr T J
University Department of Neurosurgery, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK.
Curr Opin Neurol. 1998 Dec;11(6):619-25. doi: 10.1097/00019052-199812000-00002.
Conventional therapies such as surgery, radiotherapy and, to a lesser extent, chemotherapy have produced significant increases in survival in patients with some types of brain tumours such as medulloblastoma. However, in many other types of brain tumour in both adults and children, the effect of these modalities has been more modest. A thorough understanding of the biology of malignant brain tumours is likely to provide the background for the development of new leads that might be amenable to therapeutic exploitation. This review examines some aspects of glioma biology that have been reported in the past 12 months, and which might be translated into clinical application.
传统疗法，如手术、放疗以及在较小程度上的化疗，已使某些类型脑肿瘤（如髓母细胞瘤）患者的生存率显著提高。然而，对于成人和儿童的许多其他类型脑肿瘤，这些治疗方式的效果则较为有限。深入了解恶性脑肿瘤的生物学特性可能为开发新的可用于治疗的方法提供背景。本综述探讨了过去12个月报道的胶质瘤生物学的某些方面，这些方面可能转化为临床应用。
