性发育期间大鼠睾丸中GD3和GM2合酶的活性

GD3 and GM2 synthase activities in rat testes during the period of sexual development.

作者信息

Gamallo L L, Trindade V M, Bernard E A

机构信息

Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

出版信息

Lipids. 1998 Nov;33(11):1089-92. doi: 10.1007/s11745-998-0309-4.

DOI:10.1007/s11745-998-0309-4

PMID:9870903

Abstract

Activities of two key enzymes of gangliosides biosynthesis were determined in rat testes during development. GD3 synthase activity was low and showed small variations with age. GM2 synthase activity increased 10-fold in testes from 10- to 30-d-old animals, showing a maximum activity at 30 d, followed by a small decrease until 45 d and then a constant activity up to adulthood. These developmental changes in the activity of both glycosyltransferases were related to the increasing complexity in the ganglioside pattern observed in rats testes during the period of sexual development.

摘要

在大鼠睾丸发育过程中，测定了神经节苷脂生物合成的两种关键酶的活性。GD3合酶活性较低，且随年龄变化较小。GM2合酶活性在10至30日龄动物的睾丸中增加了10倍，在30日龄时达到最高活性，随后略有下降直至45日龄，然后直至成年保持恒定活性。在性发育期间，大鼠睾丸中观察到的神经节苷脂模式的复杂性增加与这两种糖基转移酶活性的这些发育变化有关。