不对称亚胺-烯反应：与手性乙醛酸衍生的α-亚氨基酯的非对映面选择性反应以及与前手性α-亚氨基酯的对映面选择性反应的不对称催化。
Asymmetric imine-ene reactions: diastereofacial selective reactions with chiral glyoxylate-derived alpha-imino esters and asymmetric catalysis of enantiofacial selective reactions with prochiral alpha-imino esters.
作者信息
Mikami K, Yajima T, Kaneko M
机构信息
Department of Chemical Technology, Tokyo Institute of Technology, Japan.
出版信息
Amino Acids. 1998;14(4):311-8. doi: 10.1007/BF01318850.
PMID:9871475
Abstract
The diastereofacial selective "imine-ene" reactions with alpha-imino esters, prepared from (-)-8-phenylmenthyl glyoxylate, are shown to provide an efficient entry to the asymmetric synthesis of alpha-amino acids. The feasibility study of the asymmetric catalysis is also reported on the enantiofacial selective ene reactions with prochiral alpha-imino esters.
摘要
由（-）-8-苯基薄荷醇乙醛酸酯制备的α-亚氨基酯的非对映面选择性“亚胺-烯”反应被证明是α-氨基酸不对称合成的有效途径。同时还报道了关于前手性α-亚氨基酯的对映面选择性烯反应的不对称催化可行性研究。
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