Zhang X, Lombardini J B
Department of Pharmacology, Texas Tech University Health Sciences Center, Lubbock, USA.
Amino Acids. 1998;15(1-2):179-86. doi: 10.1007/BF01345290.
Alveolar macrophages isolated by pulmonary lavage from partially taurine-depleted rats demonstrated increased (2-2.6 fold) chemiluminescence due to the extracellular reaction between exogenous zymosan and various reactive forms of oxygen compared to macrophages isolated from control animals. Partial taurine depletion was achieved by adding 3% beta-alanine to the drinking water of the rats for 5 weeks prior to harvesting the macrophages. Superoxide dismutase activity was not increased in the lung tissue of the taurine-depleted rats. These data suggest that taurine has antioxidant properties and that taurine depletion is potentially deleterious to alveolar macrophages and pulmonary tissue.
与从对照动物分离的巨噬细胞相比，通过肺灌洗从部分缺乏牛磺酸的大鼠分离的肺泡巨噬细胞，由于外源性酵母聚糖与各种活性氧形式之间的细胞外反应，其化学发光增加（2 - 2.6倍）。在收获巨噬细胞前5周，通过向大鼠饮用水中添加3%β-丙氨酸来实现部分牛磺酸缺乏。牛磺酸缺乏的大鼠肺组织中超氧化物歧化酶活性没有增加。这些数据表明牛磺酸具有抗氧化特性，且牛磺酸缺乏可能对肺泡巨噬细胞和肺组织有害。
