含有8-氧代-7,8-二氢鸟苷和8-氧代-7,8-二氢-2'-O-甲基鸟苷的寡核糖核苷酸：合成及碱基配对特性
Oligoribonucleotides containing 8-oxo-7,8-dihydroguanosine and 8-oxo-7,8-dihydro-2'-O-methylguanosine: synthesis and base pairing properties.
作者信息
Kim S K, Yokoyama S, Takaku H, Moon B J
机构信息
Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu, Korea.
出版信息
Bioorg Med Chem Lett. 1998 Apr 21;8(8):939-44. doi: 10.1016/s0960-894x(98)00150-4.
PMID:9871516
Abstract
7,8-Dihydroguanosine(8-oxoG) and 7,8-dihydro-2'-O-methylguanosine (8-oxoG-Me) were chemically synthesized. Oligoribonucleotides which contain 8-oxoG or 8-oxoG-Me were synthesized. Incorporation of nucleotides opposite 8-oxoG and 8-oxoG-Me with dNTP by MMLV reverse transcriptase during cDNA synthesis was characterized.
摘要
7,8-二氢鸟苷（8-氧代鸟嘌呤）和7,8-二氢-2'-O-甲基鸟苷（8-氧代鸟嘌呤-甲基）经化学合成。合成了含有8-氧代鸟嘌呤或8-氧代鸟嘌呤-甲基的寡核糖核苷酸。对在cDNA合成过程中MMLV逆转录酶将dNTP与8-氧代鸟嘌呤和8-氧代鸟嘌呤-甲基相对应的核苷酸掺入进行了表征。
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