一种用于研究甜味的标记胍配体。

A labeled guanidine ligand for studying sweet taste.

作者信息

Feng Y, Burgess K, Pledger D, Cairns N, Linthicum D S

机构信息

Department of Chemistry, Texas A & M University, College Station 77842, USA.

出版信息

Bioorg Med Chem Lett. 1998 Apr 7;8(7):881-4. doi: 10.1016/s0960-894x(98)00130-9.

DOI:10.1016/s0960-894x(98)00130-9

PMID:9871559

Abstract

A synthesis of a biotinylated-, coumarin-substituted-N,N'-diarylguanidine 1 is reported. This ligand has structural features conducive to studying sweet taste including a fluorescent tag to facilitate spectroscopic studies of binding to protein-receptors for sweet ligands and an anchor for affinity purification.

摘要

报道了一种生物素化、香豆素取代的N,N'-二芳基胍1的合成。该配体具有有助于研究甜味的结构特征，包括一个荧光标签以促进与甜味配体的蛋白质受体结合的光谱研究，以及一个用于亲和纯化的锚定基团。