对持续感染淋巴细胞性脉络丛脑膜炎病毒的幼仓鼠肾细胞的分析。
Analysis of baby hamster kidney cells persistently infected with lymphocytic choriomeningitis virus.
作者信息
Stanwick T L, Kirk B E
出版信息
J Gen Virol. 1976 Sep;32(3):361-7. doi: 10.1099/0022-1317-32-3-361.
Baby hamster kidney cells were persistently infected with lymphocytic choriomeningitis (LCM) virus (BHKpi cells). After 21 passages of the BHKpi cells infectious virus could no longer be detected; however, the cultures continued to produce LCM virus particles which interfered with the replication of infectious LCM virus in BHKpi cells and protected mice from a subsequent intracranial inoculation of infectious LCM virus. Cultures of BHKpi cells appeared to consist of three cell populations: uninfected cells, infected cells containing infectious LCM virus, and infected cells releasing interfering particles of LCM virus.
仓鼠肾细胞被淋巴细胞性脉络丛脑膜炎（LCM）病毒持续感染（BHKpi细胞）。在BHKpi细胞传代21次后，不再能检测到感染性病毒；然而，培养物继续产生LCM病毒颗粒，这些颗粒干扰感染性LCM病毒在BHKpi细胞中的复制，并保护小鼠免受随后颅内接种感染性LCM病毒的影响。BHKpi细胞培养物似乎由三种细胞群体组成：未感染细胞、含有感染性LCM病毒的感染细胞以及释放LCM病毒干扰颗粒的感染细胞。
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