• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Syntheses of D- and L-myo-inositol 1,2,4,5-tetrakisphosphate and stereoselectivity of the I(1,4,5)P3 receptor binding.

作者信息

Chung S K, Shin B G, Chang Y T, Suh B C, Kim K T

机构信息

Department of Chemistry, Pohang University of Science & Technology, Korea.

出版信息

Bioorg Med Chem Lett. 1998 Mar 17;8(6):659-62. doi: 10.1016/s0960-894x(98)00081-x.

DOI:10.1016/s0960-894x(98)00081-x
PMID:9871578
Abstract

D- and L-myo-Inositol 1,2,4,5-tetrakisphosphate [D- & L-I(1,2,4,5)P4], which are analogues of D-myo-Inositol 1,4,5-trisphosphate [D-I(1,4,5)P3], a calcium mobilizing second messenger, were synthesized via resolution of the camphanate ester of a myo-inositol derivative, and the binding affinities to I(1,4,5)P3 receptor were measured.

摘要

相似文献

1
Syntheses of D- and L-myo-inositol 1,2,4,5-tetrakisphosphate and stereoselectivity of the I(1,4,5)P3 receptor binding.
Bioorg Med Chem Lett. 1998 Mar 17;8(6):659-62. doi: 10.1016/s0960-894x(98)00081-x.
2
Binding and activity of the nine possible regioisomers of myo-inositol tetrakisphosphate at the inositol 1,4,5-trisphosphate receptor.肌醇四磷酸的九种可能区域异构体在肌醇1,4,5-三磷酸受体上的结合与活性
Cell Calcium. 1997 Apr;21(4):301-10. doi: 10.1016/s0143-4160(97)90118-4.
3
Synthesis, calcium mobilizing, and physicochemical properties of D-chiro-inositol 1,3,4,6-tetrakisphosphate, a novel and potent ligand at the D-myo-inositol 1,4,5-trisphosphate receptor.D-手性肌醇1,3,4,6-四磷酸酯（一种新型强效的D-肌醇1,4,5-三磷酸酯受体配体）的合成、钙动员及物理化学性质
J Med Chem. 1999 Jun 3;42(11):1991-8. doi: 10.1021/jm980733i.
4
Enantiomers of myo-inositol-1,3,4-trisphosphate and myo-inositol-1,4,6 -trisphosphate: stereospecific recognition by cerebellar and platelet myo-inositol-1,4,5-trisphosphate receptors.肌醇-1,3,4-三磷酸和肌醇-1,4,6-三磷酸的对映体：小脑和血小板肌醇-1,4,5-三磷酸受体的立体特异性识别
Mol Pharmacol. 1996 Nov;50(5):1223-30.
5
Molecular recognition at the myo-inositol 1,4,5-trisphosphate receptor. 3-position substituted myo-inositol 1,4,5-trisphosphate analogues reveal the binding and Ca2+ release requirements for high affinity interaction with the myo-inositol 1,4,5-trisphosphate receptor.肌醇 1,4,5-三磷酸受体的分子识别。3-位取代的肌醇 1,4,5-三磷酸类似物揭示了与肌醇 1,4,5-三磷酸受体高亲和力相互作用的结合和 Ca2+ 释放要求。
J Biol Chem. 1994 Oct 28;269(43):26815-21.
6
Molecular interactions of endogenous D-myo-inositol phosphates with the intracellular D-myo-inositol 1,4,5-trisphosphate recognition site.内源性D-肌醇磷酸酯与细胞内D-肌醇1,4,5-三磷酸识别位点的分子相互作用。
Biochemistry. 1994 Sep 27;33(38):11586-97. doi: 10.1021/bi00204a021.
7
Inositol-1,3,4,5-tetrakisphosphate induces calcium mobilization via the inositol-1,4,5-trisphosphate receptor in SH-SY5Y neuroblastoma cells.肌醇-1,3,4,5-四磷酸通过肌醇-1,4,5-三磷酸受体在SH-SY5Y神经母细胞瘤细胞中诱导钙动员。
Mol Pharmacol. 1993 Oct;44(4):810-7.
8
Myo-inositol 1,3,4,5-tetrakisphosphate can independently mobilise intracellular calcium, via the inositol 1,4,5-trisphosphate receptor: studies with myo-inositol 1,4,5-trisphosphate-3-phosphorothioate and myo-inositol hexakisphosphate.肌醇1,3,4,5-四磷酸可通过肌醇1,4,5-三磷酸受体独立动员细胞内钙：使用肌醇1,4,5-三磷酸-3-硫代磷酸酯和肌醇六磷酸的研究。
FEBS Lett. 1993 Dec 27;336(2):267-71. doi: 10.1016/0014-5793(93)80817-e.
9
Differential stereoselectivity of D- and L-myo-inositol 1,2,4, 5-tetrakisphosphate binding to the inositol 1,4,5-trisphosphate receptor and 3-kinase.D-和L-肌醇1,2,4,5-四磷酸与肌醇1,4,5-三磷酸受体及3-激酶结合的差异立体选择性
Neurochem Int. 2000 Jul;37(1):47-52. doi: 10.1016/s0197-0186(00)00004-8.
10
DL-myo-inositol 1,2,4,5-tetrakisphosphate, a potent analog of D-myo-inositol 1,4,5-trisphosphate.DL-肌醇1,2,4,5-四磷酸，一种有效的D-肌醇1,4,5-三磷酸类似物。
Mol Pharmacol. 1994 Feb;45(2):271-6.

引用本文的文献

1
Useful access to enantiomerically pure protected inositols from carbohydrates: the aldohexos-5-uloses route.从碳水化合物中获得对映体纯的保护型肌醇的有效方法：己醛糖-5-ulose途径。
Beilstein J Org Chem. 2016 Nov 8;12:2343-2350. doi: 10.3762/bjoc.12.227. eCollection 2016.