Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists.
作者信息
Liverton N J, Armstrong D J, Claremon D A, Remy D C, Baldwin J J, Lynch R J, Zhang G, Gould R J
机构信息
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.
出版信息
Bioorg Med Chem Lett. 1998 Mar 3;8(5):483-6. doi: 10.1016/s0960-894x(98)00047-x.
PMID:9871603
Abstract
The synthesis and biological activity of a series of 3,6-substituted quinazolinediones and quinazolinones are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of these structures as central templates for nonpeptide RGD mimics.
摘要
相似文献
1
Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists.
Bioorg Med Chem Lett. 1998 Mar 3;8(5):483-6. doi: 10.1016/s0960-894x(98)00047-x.
2
Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes.
Bioorg Med Chem Lett. 2002 Apr 8;12(7):1103-7. doi: 10.1016/s0960-894x(02)00095-1.
3
Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: design of potent and specific 3,9-diazaspiro[5.5]undecanes.螺环非肽糖蛋白IIb-IIIa拮抗剂。第1部分：强效和特异性3,9-二氮杂螺[5.5]十一烷的设计。
Bioorg Med Chem Lett. 2001 May 21;11(10):1289-92. doi: 10.1016/s0960-894x(01)00215-3.
4
Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 2: design of potent antagonists containing the 3-azaspiro[5.5]undecanes.
Bioorg Med Chem Lett. 2001 May 21;11(10):1293-6. doi: 10.1016/s0960-894x(01)00216-5.
5
Platelet glycoprotein IIb/IIIa receptor antagonists derived from isoxazolidines.源自异恶唑烷的血小板糖蛋白IIb/IIIa受体拮抗剂。
Bioorg Med Chem Lett. 1999 Jan 4;9(1):55-8. doi: 10.1016/s0960-894x(98)00686-6.
6
Synthesis, biological evaluation and molecular docking studies of 2-piperazin-1-yl-quinazolines as platelet aggregation inhibitors and ligands of integrin αIIbβ3.2-哌嗪-1-基喹唑啉类化合物作为血小板聚集抑制剂和整合素αIIbβ3配体的合成、生物学评价及分子对接研究
Bioorg Med Chem Lett. 2016 Apr 1;26(7):1839-43. doi: 10.1016/j.bmcl.2016.02.011. Epub 2016 Feb 22.
7
Peptidomimetics - antagonists of the fibrinogen receptors: molecular design, structures, properties and therapeutic applications.拟肽——纤维蛋白原受体拮抗剂：分子设计、结构、性质及治疗应用
Curr Med Chem. 2004 May;11(9):1183-211. doi: 10.2174/0929867043365314.
8
Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists.在血小板糖蛋白IIb-IIIa受体拮抗剂设计中使用构象受限的苯甲脒作为精氨酸替代物。
J Med Chem. 1997 Aug 29;40(18):2843-57. doi: 10.1021/jm970020k.
9
Synthesis and pharmacology of modified amidine isoxazoline glycoprotein IIb/IIIa receptor antagonists.修饰的脒基异恶唑啉糖蛋白IIb/IIIa受体拮抗剂的合成与药理学
Bioorg Med Chem Lett. 2001 Aug 20;11(16):2201-4. doi: 10.1016/s0960-894x(01)00406-1.
10
Novel non-peptide fibrinogen receptor antagonists. 1. Synthesis and glycoprotein IIb-IIIa antagonistic activities of 1,3,4-trisubstituted 2-oxopiperazine derivatives incorporating side-chain functions of the RGDF peptide.新型非肽类纤维蛋白原受体拮抗剂。1. 结合RGDF肽侧链功能的1,3,4-三取代2-氧代哌嗪衍生物的合成及糖蛋白IIb-IIIa拮抗活性
J Med Chem. 1998 Feb 12;41(4):489-502. doi: 10.1021/jm970235u.
引用本文的文献
1
A binuclear aluminium complex as a single competent catalyst for efficient synthesis of urea, biuret, isourea, isothiourea, phosphorylguanidine, and quinazolinones.一种双核铝配合物作为单一高效催化剂用于高效合成尿素、缩二脲、异脲、异硫脲、磷酰胍和喹唑啉酮。
RSC Adv. 2023 Jan 19;13(5):3020-3032. doi: 10.1039/d2ra07714k. eCollection 2023 Jan 18.
2
Discovery of Quinazoline-2,4(1,3)-Dione Derivatives as Potential Antibacterial Agent: Design, Synthesis, and Their Antibacterial Activity.喹唑啉-2,4(1,3)-二酮衍生物的发现作为潜在的抗菌剂：设计、合成及其抗菌活性。
Molecules. 2022 Jun 15;27(12):3853. doi: 10.3390/molecules27123853.
3
A One-Pot Synthesis of Oxazepine-Quinazolinone bis-Heterocyclic Scaffolds via Isocyanide-Based Three-Component Reactions.通过基于异腈的三组分反应一锅法合成恶唑并氮杂卓-喹唑啉酮双杂环骨架
Front Chem. 2019 Sep 18;7:623. doi: 10.3389/fchem.2019.00623. eCollection 2019.
4
Bismuth-Catalyzed Synthesis of 2-Substituted Quinazolinones.铋催化合成2-取代喹唑啉酮
Tetrahedron Lett. 2018 Oct 17;59(42):3801-3805. doi: 10.1016/j.tetlet.2018.09.014. Epub 2018 Sep 7.
5
Advances in metal-catalyzed cross-coupling reactions of halogenated quinazolinones and their quinazoline derivatives.卤代喹唑啉酮及其喹唑啉衍生物的金属催化交叉偶联反应进展
Molecules. 2014 Oct 29;19(11):17435-63. doi: 10.3390/molecules191117435.
6
Hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of thioethers and ethers from quinazolin-4(3H)-ones.六氯环三磷腈（HCCP）介导的喹唑啉-4(3H)-酮的硫醚和醚的直接形成。
Molecules. 2013 May 15;18(5):5580-93. doi: 10.3390/molecules18055580.
7
3-Amino-2-methyl-4-oxo-3,4-dihydro-quinazolin-1-ium p-toluene-sulfonate monohydrate.3-氨基-2-甲基-4-氧代-3,4-二氢喹唑啉-1-鎓对甲苯磺酸盐一水合物
Acta Crystallogr Sect E Struct Rep Online. 2009 Apr 18;65(Pt 5):o1051. doi: 10.1107/S1600536809013841.
Zotero 插件