六氯环三磷腈（HCCP）介导的喹唑啉-4(3H)-酮的硫醚和醚的直接形成。
Hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of thioethers and ethers from quinazolin-4(3H)-ones.
机构信息
State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China.
出版信息
Molecules. 2013 May 15;18(5):5580-93. doi: 10.3390/molecules18055580.
A hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of quinazoline (thio)ethers from quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, diisopropylethylamine (DIPEA), and thiophenols resulted in formation of the corresponding 4-arylthioquinazoline derivatives in moderate to excellent yields. This method has also been utilized to prepare 4-aryloxyquinazoline and 4-alkoxyquinazoline derivatives using phenols and sodium alkoxides as the nucleophiles.
六氯环三磷腈（HCCP）介导的喹唑啉-4（3H）-酮直接形成喹唑啉（硫）醚已被开发。喹唑啉-4（3H）-酮与 HCCP、二异丙基乙胺（DIPEA）和苯硫酚反应，以中等至优异的产率生成相应的 4-芳基硫代喹唑啉衍生物。该方法还可用于使用酚和醇盐作为亲核试剂制备 4-芳氧基喹唑啉和 4-烷氧基喹唑啉衍生物。
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