具有磷酸二酯主链的拟肽低聚物的固相合成。
Solid-phase synthesis of peptidomimetic oligomers with a phosphodiester backbone.
作者信息
Lin P, Ganesan A
机构信息
Institute of Molecular and Cell Biology, National University of Singapore, Singapore.
出版信息
Bioorg Med Chem Lett. 1998 Mar 3;8(5):511-4. doi: 10.1016/s0960-894x(98)00064-x.
PMID:9871608
Abstract
An unnatural biopolymer is described in which amino acid side-chains are presented along a negatively charged phosphodiester backbone. For this purpose, a series of phosphoramidite monomers was prepared from chiral 1,2-diols. These were efficiently converted into oligomers using standard coupling conditions on an automated DNA synthesizer.
摘要
描述了一种非天然生物聚合物，其中氨基酸侧链沿带负电荷的磷酸二酯主链排列。为此，从手性1,2 -二醇制备了一系列亚磷酰胺单体。使用标准偶联条件在自动DNA合成仪上，将这些单体有效地转化为低聚物。
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