Lohray B B, Baskaran S, Rao B S, Mallesham B, Bharath K S, Reddy B Y, Venkateswarlu S, Sadhukhan A K, Kumar M S, Sarnaik H M
Department of Medicinal Chemistry and Drug Discovery, Dr. Reddy's Research Foundation, Hyderabad, India.
Bioorg Med Chem Lett. 1998 Mar 3;8(5):525-8. doi: 10.1016/s0960-894x(98)00063-8.
Several 7-(3R,4R-N,N'-dialkyl diaminopyrrolidinyl)-substituted quinolones were synthesized and evaluated for antibacterial activities. 5-Amino-7-(3R,4R-N,N'-dimethyldiamino-6,8-difluoro-1,4-dihydro-1-c yclopropyl -4-oxoquinoline-3-carboxylic acid was found to have potent antibacterial activity against gram +ve organisms.
合成了几种7-(3R,4R-N,N'-二烷基二氨基吡咯烷基)取代的喹诺酮类化合物，并对其抗菌活性进行了评估。发现5-氨基-7-(3R,4R-N,N'-二甲基二氨基-6,8-二氟-1,4-二氢-1-环丙基-4-氧代喹啉-3-羧酸对革兰氏阳性菌具有强效抗菌活性。
