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New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.

作者信息

Mewshaw R E, Husbands M, Gildersleeve E S, Webb M B, Shi X, Mazandarani H, Cockett M I, Ochalski R, Brennan J A, Abou-Gharbia M, Marquis K, McGaughey G B, Coupet J, Andree T H

机构信息

Global Chemical Sciences Department, Wyeth-Ayerst Research Laboratories, Princeton, New Jersey 08543-8000, USA.

出版信息

Bioorg Med Chem Lett. 1998 Feb 3;8(3):295-300. doi: 10.1016/s0960-894x(98)00014-6.

DOI:10.1016/s0960-894x(98)00014-6
PMID:9871673
Abstract

Described in this report is a systematic study which led to the identification of two new dopamine D2 partial agonists (5 and 17). Phenols 5 and 17 represent prototypes of two new classes of D2 partial agonists as well as templates for the future design of novel dopaminergic agents.

摘要

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