Synthesis of Dolastatin 15 mimetic peptoids.
作者信息
Schmitt J, Bernd M, Kutscher B, Kessler H
机构信息
Institut für Organische Chemie und Biochemie Technischen Universität München, Garching, Germany.
出版信息
Bioorg Med Chem Lett. 1998 Feb 17;8(4):385-8. doi: 10.1016/s0960-894x(98)00034-1.
PMID:9871690
Abstract
Eight peptoids have been synthesized as peptidomimetics of the cytostatic Dolastatin 15, a depsipeptide isolated from the Indian sea hare Dolabella auricularia. The compounds have been tested against several human cancer cell lines and did not show any cytostatic properties.
摘要
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