冈田酸的络合作用：一项初步研究。
Complexation of okadaic acid: a preliminary study.
作者信息
Norte M, Fernández J J, Souto M L, Gavín J A, Candenas M L, Ausina P
机构信息
Instituto Universitario de Bioorgánica Antonio González, Universidad de La Laguna, Tenerife, Spain.
出版信息
Bioorg Med Chem Lett. 1998 May 5;8(9):1007-12. doi: 10.1016/s0960-894x(98)00152-8.
PMID:9871698
Abstract
A complexation study was carried out with okadaic acid (OA) and the univalent metal ions Li+, Na+ and K+, and the divalent metal ions Ca2+ and Mg2+. K+ binding was observed identical with a complex obtained from the natural source (OAC). The pharmacological trials demonstrated that this cation has a very important influence on the pharmacological activity of okadaic acid.
摘要
开展了一项关于冈田酸（OA）与单价金属离子Li⁺、Na⁺和K⁺以及二价金属离子Ca²⁺和Mg²⁺的络合研究。观察到K⁺的结合与从天然来源获得的一种络合物（OAC）相同。药理试验表明，这种阳离子对冈田酸的药理活性有非常重要的影响。
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