Van Haver D, De Clercq P J
University of Gent, Department of Organic Chemistry, Belgium.
Bioorg Med Chem Lett. 1998 May 5;8(9):1029-34. doi: 10.1016/s0960-894x(98)00155-3.
Dot maps used to represent the calculated conformations of the side chain of vitamin D derivatives are improved by replacing dots by coloured balls to create volume maps and to identify particular energy windows. Two procedures to define a relative activity volume, based on a pair of analogs with distinctly different biological activity and conformational behaviour, are presented.
通过用彩色球取代点来创建体积图并识别特定能量窗口，可改进用于表示维生素D衍生物侧链计算构象的点图。本文提出了两种基于一对具有明显不同生物活性和构象行为的类似物来定义相对活性体积的方法。
