抗炎/抗关节炎酮基双膦酸酯。
Anti-inflammatory/antiarthritic ketonic bisphosphonic acid esters.
作者信息
Schlachter S T, Galinet L A, Shields S K, Aspar D G, Dunn C J, Staite N D, Nugent R A
机构信息
Pharmacia & Upjohn, Kalamazoo, MI 49001, USA.
出版信息
Bioorg Med Chem Lett. 1998 May 5;8(9):1093-6. doi: 10.1016/s0960-894x(98)00167-x.
PMID:9871714
Abstract
Bisphosphonate ester 2 is an inhibitor of inflammation, but is devoid of antiarthritic effects. SAR studies on a series of related bisphosphonate esters resulted in compounds 6e, 6i, 6j, and 6m, which exhibited excellent inhibition of an arthritis model, in addition to potent anti-inflammatory effects.
摘要
双膦酸酯2是一种炎症抑制剂，但没有抗关节炎作用。对一系列相关双膦酸酯的构效关系研究产生了化合物6e、6i、6j和6m，这些化合物除了具有强效抗炎作用外，还对关节炎模型表现出优异的抑制作用。
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