含β-二氟的氨基酸的合成。

Synthesis of beta-difluorine-containing amino acids.

作者信息

Li K, Leriche C, Liu H

机构信息

University of Minnesota, Department of Chemistry, Minneapolis 55455, USA.

出版信息

Bioorg Med Chem Lett. 1998 May 5;8(9):1097-100. doi: 10.1016/s0960-894x(98)00168-1.

DOI:10.1016/s0960-894x(98)00168-1

PMID:9871715

Abstract

A convenient strategy was developed to prepare several beta-difluoroamino acids. As exemplified by the synthesis of 3,3-difluoro-L-homocysteine, 3,3-difluoro-L-homoserine and 3,3-difluoro-L-methionine, the reaction sequence all started from L-isoascorbic acid. This approach holds potential to be extended to make other beta-difluorine-containing amino acids.

摘要

已开发出一种便捷策略来制备多种β-二氟氨基酸。以3,3-二氟-L-高半胱氨酸、3,3-二氟-L-高丝氨酸和3,3-二氟-L-甲硫氨酸的合成为例，反应序列均从L-异抗坏血酸开始。这种方法有潜力扩展用于制备其他含β-二氟的氨基酸。