Basten J E, Dreef-Tromp C M, de Wijs B, van Boeckel C A
N.V. Organon Scientific Development Group, The Netherlands.
Bioorg Med Chem Lett. 1998 May 19;8(10):1201-6. doi: 10.1016/s0960-894x(98)00196-6.
The syntheses of several heparin-like glycoconjugates (i.e., 16a-f) containing identical AT III binding domains (ABD) and spacers but different thrombin binding domains (TBDs) are described. Biological activities of conjugates 16a-f indicate that the thrombin inhibitory activity is mainly determined by the charge density of the TBD moiety.
本文描述了几种含有相同抗凝血酶III结合域（ABD）和间隔区但不同凝血酶结合域（TBD）的类肝素糖缀合物（即16a - f）的合成。16a - f缀合物的生物学活性表明，凝血酶抑制活性主要由TBD部分的电荷密度决定。
