抗幽门螺杆菌药物。2. 新型2-烷基胍基-4-呋喃基噻唑系列的构效关系
Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles.
作者信息
Katsura Y, Nishino S, Tomishi T, Sakane K, Matsumoto Y, Ishikawa H, Takasugi H
机构信息
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
出版信息
Bioorg Med Chem Lett. 1998 Jun 2;8(11):1307-12. doi: 10.1016/s0960-894x(98)00206-6.
SAR for antimicrobial activity against H. pylori was investigated in a new series of 2-alkylguanidino-4-furylthiazoles. Of the compounds obtained, cyclohexylmethyl and ethoxyethyl derivatives were identified as a novel class of anti-H. pylori agents which possessed potent and selective antimicrobial activity against H. pylori. These compounds also showed gastric antisecretory activity.
在一系列新的2-烷基胍基-4-呋喃基噻唑中研究了对幽门螺杆菌的抗菌活性的构效关系。在所得到的化合物中，环己基甲基和乙氧基乙基衍生物被鉴定为一类新型的抗幽门螺杆菌剂，它们对幽门螺杆菌具有强效和选择性抗菌活性。这些化合物还表现出胃抗分泌活性。
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