胰凝乳蛋白酶在聚乙烯亚胺衍生物微区中的激活与稳定。体内环境模型。
Activation and stabilization of chymotrypsin in microdomains of poly(ethylenimine) derivatives. A model of in vivo environment.
作者信息
Suh J, Lee Y, Han S
机构信息
Department of Chemistry, Seoul National University, Korea.
出版信息
Bioorg Med Chem Lett. 1998 Jun 2;8(11):1331-6. doi: 10.1016/s0960-894x(98)00211-x.
PMID:9871761
Abstract
Both activity and stability of alpha-Chymotrypsin (ChT) are substantially enhanced in the microdomains of laurylated or benzylated derivatives of poly(ethylenimine). EPR data revealed that the enhancement in activity of ChT is due to increase in the polarity of the microenvironment of Ser-195 caused by complexation of ChT to the polymer derivatives.
摘要
在聚乙烯亚胺的月桂酰化或苄基化衍生物的微区中，α-胰凝乳蛋白酶（ChT）的活性和稳定性均得到显著增强。电子顺磁共振（EPR）数据表明，ChT活性的增强是由于ChT与聚合物衍生物络合导致Ser-195微环境极性增加所致。
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