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Synthesis and biological evaluation of 1,2-disubstituted carbonucleosides of 2-amino-6-substituted purine and 8-azapurine.

作者信息

Santana L, Teijeira M, Uriarte E, Balzarini J, De Clercq E

机构信息

Laboratorio de Química Farmaceútica, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.

出版信息

Bioorg Med Chem Lett. 1998 Jun 2;8(11):1349-52. doi: 10.1016/s0960-894x(98)00216-9.

DOI:10.1016/s0960-894x(98)00216-9
PMID:9871764
Abstract

One, two-disubstituted carbocyclic nucleoside analogues bearing a 2-amino-6-substituted (chloro, hydroxy or amino) purine or 8-azapurine base were prepared by constructing the base about (+/-)-2-aminocyclopentane methanol, and their activities against a selection of viruses and tumor cells were determined in vitro.

摘要

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